Relative Bioavailability of Pioglitazone After Co-administration With Different Doses of BI 10773 in Healthy Volunteers

Inclusion Criteria: 1. Healthy male subjects according to the following criteria: medical history, physical examination, vital signs ((blood pressure (BP), pulse rate (PR), 12-lead electrocardiogram (ECG)), clinical laboratory tests 2. Age 18 to 55 years (incl.) 3. BMI 18.5 to 29.9 kg/m2 (incl.) 4. Signed and dated written informed consent prior to admission to the study in accordance with Good Clinical Practise (GCP) and the local legislation Exclusion Criteria: 1. Any finding of the medical examination including blood pressure (BP), pulse rate (PR) and electrocardiogram (ECG) deviating from normal and of clinical relevance 2. Any evidence of a clinically relevant concomitant disease 3. Gastrointestinal, hepatic, renal, respiratory, cardiovascular, metabolic, immunological or hormonal disorders 4. Surgery of the gastrointestinal tract (except appendectomy) 5. Diseases of the central nervous system (such as epilepsy) or psychiatric disorders or neurological disorders 6. History of relevant orthostatic hypotension, fainting spells or blackouts. 7. Chronic or relevant acute infections 8. History of relevant allergy/hypersensitivity (including allergy to drug or its excipients) 9. Intake of drugs with a long half-life (more than 24 hours) within at least one month or less than 10 half-lives of the respective drug prior to administration or during the trial 10. Participation in another trial with an investigational drug within two months prior to administration or during the trial 11. Smoker (more than 10 cigarettes or more than 3 cigars or more than 3 pipes/day) 12. Inability to refrain from smoking on trial days 13. Alcohol abuse (more than 30 g/day) 14. Drug abuse 15. Blood donation (more than 100 mL within four weeks prior to administration or during the trial) 16. Excessive physical activities (within one week prior to administration or during the trial) 17. Alanine aminotransferase (ALT) outside the normal range or any other laboratory value outside the reference range that is of clinical relevance 18. Inability to comply with dietary regimen of trial site 19. Galactose or lactose intolerance, galactose or glucose malabsorption