BI 10773 Administered as Oral Solution to Healthy Male Volunteers

Inclusion Criteria: * Healthy males according to a complete medical history, including a physical examination, vital signs (blood pressure, pulse rate), 12-lead ECG (electrocardiogram), and clinical laboratory tests * Age 18 to 55 years, inclusive * Body mass index 18.5 to 29.9 kg/m2, inclusive * Nonsmoker * Signed and dated written informed consent prior to admission to the study in accordance with GCP (Good Clinical Practice) and the local legislation Exclusion Criteria: * Any finding in the medical examination (including blood pressure, pulse rate and ECG) deviating from normal and of clinical relevance * Any evidence of a clinically relevant concomitant disease * Gastrointestinal, hepatic, renal, respiratory, cardiovascular, metabolic, immunological, hormonal, psychiatric or neurological disorders (including all forms of epilepsy) * Surgery of the gastrointestinal tract (except appendectomy) * History of relevant orthostatic hypotension, fainting spells or blackouts * Subjects with Gilbert's Syndrome * Chronic or relevant acute infections * History of relevant allergy/hypersensitivity (including allergy to drug or its excipients) * Intake of drugs with a long half-life (\>24 hours) within one month prior to administration of the trial drug * Use of prescription medication, over-the-counter drugs or herbal preparations within 14 days prior to administration of the trial drug * Participation in another trial with an investigational drug within two months prior to administration of the trial drug or during the trial * History or evidence of habitual tobacco or nicotine use within six months prior to administration of the trial drug * Alcohol abuse (more than 60 g/day) * Drug abuse in opinion of investigator * Blood donation (more than 100 mL within four weeks prior to administration of trial drug or during the trial) * Excessive physical activity within five days prior to administration of trial drug * Any laboratory value outside the reference range that is of clinical relevance * Inability to comply with dietary regimen of trial centre * A marked baseline prolongation of QT/QTc interval (corrected QT interval)(e.g., repeated demonstration of a QTc interval \>450 ms) * Male subjects must agree to minimise the risk of female partners becoming pregnant from the dosing day until three months after the completion of the study. Acceptable methods of contraception for male volunteers include a vasectomy no less than three months prior to dosing, barrier contraception, or a medically accepted contraceptive method. For female partners of male volunteers, acceptable methods of contraception include intrauterine device, tubal ligation, hormonal contraceptive for at least two months, or diaphragm with spermicide * Participation in more than one other radiolabeled investigational drug trial within one year prior to administration of the trial drug. The previous radiolabeled trial drug must have been received more than six months prior to administration of the trial drug for this study, and the total exposure from this study and the previous study will be within the recommended levels considered safe, per 21 CFR (Code of Federal Regulations) 361.1 (eg, less than 5000 mrem whole body annual exposure) * Irregular defecation pattern (less than one bowel movement a day)