Tiotropium in Combination With Concomitant Cimetidine or Ranitidine in Healthy Male and Female Subjects

Inclusion Criteria: * Healthy males or females * Age range from 50 to 65 years * Within 20% of their normal weight (Broca index) Exclusion Criteria: * Any finding of the medical examination (including blood pressure, puls rate and ECG) deviating from normal and of clinical relevance * Gastrointestinal, hepatic, renal, respiratory, cardiovascular, metabolic, immunological or hormonal disorders * Diseases of the central nervous system (such as epilepsy) or with psychiatric disorders or neurological disorders * History of orthostatic hypotension, fainting spells or blackouts * Chronic or relevant acute infections * History of allergy/hypersensitivity (including drug allergy) which is deemed relevant to the trial as judged by the investigator * Intake of a drug with a long half-life (≥ 24 hours) within ten half-lives of the respective drug before enrolment in the study or during the study (exclusion: ovarian hormone substitution) * Use of any drugs which might influence the results of the trial within four weeks prior to administration or during the trial, among these all non-selective β-blockers, cromolyn sodium, nedocromil sodium, oral β-adrenergics or long-acting β-adrenergics such as salmeterol and formoterol, and anticholinergic drugs including ATROVENT® (ipratropium) by oral inhalation or ATROVENT® Nasal Spray * Participation in another study with an investigational drug within two months prior to administration or during the trial * Smoker (\> 10 cigarettes or 3 cigars or 3 pipes/day) * Inability to refrain from smoking on study days * Alcohol abuse (\> 40 g/day) * Drug abuse * Blood donation (≥ 100 ml) within four weeks prior to administration or during the trial * Excessive physical activities within 5 days prior to administration or during the trial * Any laboratory value outside the reference range of clinical relevance * Subjects with known hypersensitivity to anticholinergic drugs * Subjects with known symptomatic prostatic hypertrophy or disturbed micturition * Subjects with known narrow-angle glaucoma In addition for female subjects (if appropriate): * Pregnancy * Positive pregnancy test * No adequate contraception e.g. oral contraceptives, sterilization, intra uterine pessary (IUP) * Inability to maintain this adequate contraception during the whole study period * Lactation period