To investigate whether increased dose of local anesthetic (lidocaine) increases duration of peripheral nerve block (adductor canal block) and to develop a model for assessing duration of peripheral nerve blockades. The investigators hypothesize that increasing the dose of lidocaine (by increased concentration) will increase the duration of an adductor canal block. The study is a follow up on an identical study (SM1-PJ-13, EudraCT number: 2013-001822-24 ) made earlier with different concentrations of lidocaine and a placebo group. For further information see trial registration at European Union Drug Regulatory Authorities Clinical Trial System.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
14
Duration of an adductor canal block with 20 ml lidocaine, single bolus, administered as 5 or 15 mg/ml
Rigshospitalet, Centre of Head and Orthopaedics, Department of Anaesthesia
Copenhagen, Denmark
Duration of sensory block assessed with pinprick.
Duration is defined as the time from block performance until recovery of sensation to pin-prick stimulus, assessed at 30 and 60 minutes post block, and thereafter every hour.
Time frame: 0-10 hours
Duration of sensory block assessed by heat pain detection threshold
Duration is defined as time from block performance until recovery of normal sensation (+/- 2 degrees Celsius from preblock value) assessed at 30 and 60 minutes post block, and thereafter every hour.
Time frame: 0-10 hours
Duration of sensory block assessed by warmth detection threshold
Duration is defined as time from block performance until recovery of normal sensation (return to baseline value + 2 degrees Celsius or less from preblock value) assessed at 30 and 60 minutes post block, and thereafter every hour.
Time frame: 0-10 hours
Duration of sensory block assessed by pain during 1 minute of warmth stimulation
Duration is defined as time from block performance until recovery of normal sensation (return to baseline VAS pain scores +/-10 mm from preblock value) assessed at 30 and 60 minutes post block, and thereafter every hour.
Time frame: 0-10 hours
Duration of sensory block assessed by tolerance to transcutaneal electrical stimulation
Duration is defined as time from block performance until recovery of normal sensation (return to baseline preblock value) assessed at 30 and 60 minutes post block, and thereafter every hour.
Time frame: 0-10 hours
Duration of sensory block assessed by cold sensation with an alcohol swab
Duration is defined as time from block performance until recovery of normal sensation assessed at 30 and 60 minutes post block, and thereafter every hour.
Time frame: 0-10 hours
Duration of motor block assessed as maximum voluntary isometric contraction.
Duration is defined as time from block performance until recovery of normal muscle strength, assessed at 30 and 60 minutes post block, and thereafter every hour.
Time frame: 0-10 hours
Time to onset of sensory block assessed by pinprick.
Onset is defined as the time from block performance until loss of sensation to pin-prick stimulus assessed at 30 and 60 minutes post block, and thereafter every hour.
Time frame: 0-2 hours
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.