Efficacy and Safety of Ba679BR Powder Inhalation in Patients With Chronic Obstructive Pulmonary Disease (COPD)

Inclusion Criteria: Diagnosis of COPD (chronic bronchitis, and emphysema) with stable symptoms: * Screening FEV1.0 ≤70% of predicted normal vale and screening FEV1.0/FVC ≤70% (the baseline FEV1.0 should also be ≤70% of predicted normal value on the initial day of administration) * Smoking history ≥ 10 pack-years (a peak-year is 20 cigarettes per day for one year or equivalent) * Male or female patients 40 years of age or older Exclusion Criteria: * History of bronchial asthma * History of an atopic disease such as allergic rhinitis * Total blood eosinophil count ≥ 600/µL * Patient treated with antiallergic drugs or anti-histamine drugs * Patients using oral corticosteroid medication at unstable doses (i.e. less than one month on a stable dose) or at a dose in excess of the equivalent of 10 mg of prednisolone per day * Patients using inhaled steroid, oral β2 stimulant, theophylline preparation, expectorant or macrolide antibiotic at unstable doses (i.e. less than one month on a stable dose) * Patients using an ACE inhibitor at unstable doses (i.e. less than one month on a stable dose) * Patients with known narrow-angle glaucoma * Patients with known symptomatic prostatic hypertrophy * Patients with known hypersensitivity to anticholinergic drugs, lactose or any other components of the inhalation capsule delivery system * Patients with significant diseases who in the opinion of the investigator were not eligible for the study * Patients with clinically significant abnormal baseline laboratory test values (hematology, blood chemistry, urinalysis). Patients with serum glutamic-oxaloacetic transaminase (SGOT) and serum glutamic-pyruvic transaminase (SGPT) twice the upper limit of the normal range, bilirubin 150% or creatinine 125% of the upper limit of the normal range were excluded * Patients with a recent history (i.e. within the 3 months prior to the screening visit) of myocardial infarction or heart failure * Patients with any cardiac arrhythmia requiring drug therapy * Patients who were treated with Patients who were treated with β-blockers-blockers * Patients with regular use of daytime oxygen therapy * Patients with known active tuberculosis or with obvious sequela of tuberculosis * Patients with a history of cancer within the last 5 years. Patients with treated basal cell carcinoma were allowed * Patients with a history of cystic fibrosis or bronchiectasis * Patients with upper respiratory tract infection in the past one month prior to the screening visit or during the baseline period * Patients who had taken an investigational drug within one month or six half lives (whichever is greater) prior to the screening visit * Pregnant or nursing women or women of childbearing potential * Other than the above, patients who in the opinion of the investigator were not eligible for the study