Randomized Multicenter Phase II/III Study With Adjuvant Gemcitabine Versus Neoadjuvant / Adjuvant FOLFIRINOX for Resectable Pancreas Carcinoma

Inclusion Criteria: 1. Histologically confirmed adenocarcinoma of the pankreas. For histological confirmation, max. 3 tests are allowed. If no confirmation of carcinoma is possible, the patient can not be included into the study. 2. Radiological confirmation of a locally limited curativ resectable (primarily resectale or borderline situation) pankreas carcinoma without distant metastases. 3. no prior pancreas resection 4. no prior cytostatic chemotherapy 5. female and male patients \> 18 and \<=75 years using contraception 6. ECOG ≤ 1 7. medical resectability 8. granulocytes \> 1.500/µl 9. thrombocytes \> 100.000/µl 10. hemoglobin ≥ 8,0 g/dl 11. serumcreatinine ≤ 1.5x of normal value or Creatinine-Clearance \> 50 ml/min 12. written informed consent Exclusion Criteria: 1. Endocrine pancreas carcinoma 2. locally advanced inoperable stages: non-resectable infiltration of V. porta or longway infiltration of A. mesenterica superior or infiltration of Truncus coeliacus. 3. distant metastases 4. Relapse 5. prior radiotherapy of measurable lesions 6. peritonealcarcinosis 7. malignant secondary disease, dated back \< 5 years (exeption: in-situ-carcinoma of the cervix, adequately treated skin basal cell carcinoma) 8. contraindication for operative resection 9. ECOG ≥ 2 10. severe liver dysfunction (AST/ALT\>3,5xULN, AP\>6xULN) 11. Transhepatic drainage 12. active CHD (symptoms present), cardiomyopathy or heart insufficiency stage III-IV according to NYHA and EF \< 45% 13. severe non-surgical accompanying diseases or acute infection 14. chronic diarrhea 15. chronic inflammable gastro-intestinal disease 16. peripheral polyneuropathy \> NCI grade II 17. pregnancy or lactation 18. hypersensibility or contraindication for Gemcitabine, Oxaliplatin, Natriumfolinate, Irinotecan or 5-Fluorouracil 19. participation in another interventional trial