Comparison of Safety and Efficacy of Berodual® Administered Via the Respimat® Device With That Administered Via the Metered Dose Inhaler (MDI) in Patients With Chronic Obstructive Pulmonary Disease (COPD)

Inclusion Criteria: * Age \>= 40 years * Diagnosis of COPD according the following criteria: * screening FEV1\<= 65% predicted * Screening FEV1/FVC \<= 70% * Smoking history \> 10 pack-years (a pack-year is 20 cigarettes per day for one year or equivalent * Able to be trained in the proper use of MDI and Respimat® * Able to be trained in the performance of technically satisfactory pulmonary function tests * All patients must be willing and able to sign informed consent in accordance with Good clinical Practice (GCP) and local legislation Exclusion Criteria: * History of cardiovascular, renal, neurologic, liver or endocrine dysfunction (e.g. hyperthyreosis) if they are clinically significant. A clinically significant disease is defined as one which in the opinion of the investigator may either put the patient at risk because of participation in the study or a disease which may influence the results or the study or the patient's ability to participate in the study * Patients with a recent (\<= one year) history of myocardial infarction * Tuberculosis with indication for treatment * History of cancer within the last five years (excluding basal carcinoma) * Patients who have undergone thoracotomy * Current psychiatric disorders * History of life-threatening pulmonary obstruction, cystic fibrosis or bronchiectasis * An upper and lower respiratory tract infection in the four weeks prior to the screening visit * Patients with known symptomatic prostatic hypertrophy or bladder neck obstruction * Patients with known narrow-angle glaucoma or raised intra-ocular pressure * Patients with clinically significant abnormal baseline haematology, blood chemistry or urinalysis, if the abnormality defines a disease listed as an exclusion criterion * Patients with: * Serum glutamic oxalo-acetic transaminase (SGOT) or serum glutamic pyruvic transaminase (SGPT) \>200% of the upper limit of the normal range * Bilirubin \>150% of the upper limit of the normal range * Creatinine \>125% of the upper limit of the normal range * Patients who are on chronic oxygen therapy * Intolerance to aerosolised ipratropium- or fenoterol-containing products, or hypersensitivity to any of the MDI ingredients * Oral corticosteroid mediation at dose greater than 10 mg prednisolone per day or equivalent * Beta-blocker medication * Changes in the pulmonary therapeutic plan within the last four weeks prior to the screening visit (not including withholding of medication before the screening visit) * Concomitant or recent (within the last month) use of investigational drugs * History of drug abuse and/or alcoholism * Pregnant or nursing women and women of child-bearing potential not using a medically approved means of contraception * Previous participation in this study (i.e. having been allocated a randomized treatment number) * Patients with a history of asthma, allergic rhinitis or atopy or who have blood eosinophil count above 600/mm3 (a repeat eosinophil count will not be conducted in these patients) and those patients on antihistamines, anti-leukotrienes, sodium cromoglycate or nedocromil sodium * Patients who are unable to comply with the medication restrictions specified in section 4.2 or who cannot use an MDI without a spacer