When a person is put on a breathing machine the investigators think that the breathing muscles can get weaker. The investigators are not sure how quickly this happens but in some people this leads to problems when they try to breathe on their own without the breathing machine. The diaphragm is at the bottom of a person's chest separating their lungs from what is in their belly and it is a very strong muscle. In fact, it is main muscle that one uses for breathing. An ultrasound machine is a painless way to see what is happening beneath the skin. It is safe and easy to do. Using an ultrasound the investigators are planning to measure how thick the diaphragm is and how much it changes while a person is on a breathing machine in the ICU. Getting a better understanding of this condition could lead to improved treatments that might help support patients who require a ventilator for breathing. The investigators hypothesis is that patients for whom the breathing machine is doing all of the work of breathing, will have their diaphragm thickness gradually decrease and changing to a breathing modem mode where they have to put in more effort the diaphragm thickness will start increasing again.
The investigators propose to expand the investigators single-centre longitudinal pilot study into a complete study in which the investigators will use B-mode ultrasonography to evaluate daily changes in diaphragm thickness in all critically ill patients on mechanical ventilation (MV) until successful weaned from MV. The impact of patient age, co-morbidities, and the use of various modes of ventilation on diaphragm thickness will be assessed. Diaphragmatic thickness and its change from baseline will be evaluated as predictors of the need for a prolonged wean (\>7days). The investigators hypothesize that in patients on mandatory mode ventilation, diaphragmatic thickness will progressively decrease. Switching from mandatory to assisted breathing modes will correlate with increases in diaphragmatic thickness.
Study Type
OBSERVATIONAL
Enrollment
61
Patient days during which only a mandatory ventilation mode was used and prior to this no voluntary mode was used.
Patient days on a voluntary mode with no preceding days with a majority of time spend on a mandatory mode
Patient days on a voluntary vent mode with at least one day prior during which the majority of the vent mode was mandatory.
Royal Columbian Hospital
New Westminster, British Columbia, Canada
US measurement of diaphragm and quadriceps thickness
Diaphragm thickness will be measured once per day and continue until extubation, liberation from mechanical ventilation, transfer to another facility, death, or study completion.
Time frame: Participants will be ultrasounded daily until they are extubated or the 3 month study period has ended, the expected average duration of mechanical ventilation is 4.4 days at our institution
Quadriceps muscle thickness
The thickness of the quadriceps muscle on ultrasound will be measured daily until patient exit from study
Time frame: Participants will be ultrasounded daily until they are extubated or the 3 month study period has ended, the expected average duration of mechanical ventilation is 4.4 days at our institution
PEEP (Postive end expiratory pressure) applied by the mechanical ventilator at the time of the ultraspound
The PEEP (as described above in the title) in cm H20 as applied by the mechanical ventilator, measured at the time of ultrasound
Time frame: Participants will be ultrasounded daily until they are extubated or the 3 month study period has ended, the expected average duration of mechanical ventilation is 4.4 days at our institution
re-intubated within 48 hours
Whether a patient required re-intubation within 48 hours of extubation
Time frame: followed for 48 hours post extubation, or 3 month study period has ended
mean daily fluid balance
Fluid balance of administer fluids minus measurable excreted fluid as recorded every 24 hours by the bedside nurse
Time frame: Will be recorded daily until they are extubated or the 3 month study period has ended, the expected average duration of mechanical ventilation is 4.4 days at our institution
mean daily FiO2 (oxygen level administered)
The daily average oxygen delivered through the mechanical ventilator to the patient.
Time frame: Will be recorded daily until they are extubated or the 3 month study period has ended, the expected average duration of mechanical ventilation is 4.4 days at our institution
mode of mechanical ventilation for >80% of the day
Mode of mechanical ventilation for the \>80% of the day will be recorded here. This will be split into a mandatory mode (where the machine supplies a breath) or a voluntary mode (where the patient triggers the breath and the machine supports it).
Time frame: Will be recorded daily until they are extubated or the 3 month study period has ended, the expected average duration of mechanical ventilation is 4.4 days at our institution
steroids given
This will include any dose of steroids administered to the patient each day during their intubation.
Time frame: Will be recorded daily until they are extubated or the 3 month study period has ended, the expected average duration of mechanical ventilation is 4.4 days at our institution
vasopressors given
This will include any dose of medications to support the blood pressure (norepinephrine, epinephrine, dopamine, dobutamine, amrinone) administered to the patient each day during their intubation.
Time frame: Will be recorded daily until they are extubated or the 3 month study period has ended, the expected average duration of mechanical ventilation is 4.4 days at our institution
paralytics given
This will include any dose of paralytic medication administered to the patient each day during their intubation, except given as part of their initial intubation
Time frame: Will be recorded daily until they are extubated or the 3 month study period has ended, the expected average duration of mechanical ventilation is 4.4 days at our institution
30 day mortality
This is to capture all cause mortality. A patient will be considered to have survived if they are discharged from hospital.
Time frame: 30 days after patient is extubated, or at the end of the follow up period 1 month after the 3 month study has ended
Body Mass Index (BMI)
The standard BMI will be recorded as determined by the clinical dietician.
Time frame: from admission information, at the time of admission to the ICU, obtained from the patient record
presence of sepsis/severe sepsis on admission
This will be determined as positive if there is any reference to infection in the patients admitting paperwork in conjunction with the classic SIRS (systemic inflammatory response syndrome) criteria.
Time frame: from admission information, at the time of admission to the ICU, obtained from the patient record.
% Caloric goals met in preceding 24 hours
A % of caloric goals delivered over the preceding 24 hours will be captured
Time frame: Will be recorded daily until they are extubated or the 3 month study period has ended, the expected average duration of mechanical ventilation is 4.4 days at our institution
Initial presence of malnutrition
Presence of malnutrition as assessed by dietician on admission
Time frame: Measure at the time of admission to the ICU
At risk for re-feeding syndrome
Presence of risk for re-feeding syndrome as assessed by dietician on admission
Time frame: Assessed on admission to the ICU
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