Leptin and Visfatin in Diabetic Patients With Periodontitis Before and After Periodontal Therapy

Cairo University50 enrolled

Overview

1. Are adipokines involved in pathogenesis of periodontal disease in diabetic patients? 2. Does their level change after periodontal therapy?

Patients with chronic periodontitis only and patients with chronic periodontitis and diabetes were evaluated for levels of leptin and visfatin in the gingival tissues before and after non-surgical periodontal therapy.

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

SINGLE

Enrollment

Conditions

Chronic Periodontitis Type 2 Diabetes Mellitus

Interventions

non-surgical periodontal therapyPROCEDURE

supra and subgingival debridement

Eligibility

Sex: ALLMin age: 35 YearsMax age: 54 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * diabetic patients having diabetes mellitus ≥5 years prior to the study. * chronic periodontitis with clinical attachment loss \> 5 mm. * otherwise systemically healthy subjects. Exclusion Criteria: * any known systemic diseases other than diabetes. * pregnancy or lactation. * smokers. * receiving periodontal treatment in the last 6 months. * taking any drugs or medications other than anti-diabetic drugs.

Locations (1)

Faculty of oral and dental medicine

Cairo, Egypt

Outcomes

Primary Outcomes

visfatin levels in gingival tissues

estimation of protein and gene expression of visfatin in patients with chronic periodontitis only and diabetic patients with periodontitis before and after non-surgical periodontal therapy..

Time frame: 3 months

leptin levels in gingival tissue

estimation of protein and gene expression of leptin in patients with chronic periodontitis only and diabetic patients with periodontitis before and after non-surgical periodontal therapy..

Time frame: 3 months

Secondary Outcomes

pocket depth

estimation of pocket depth in patients with chronic periodontitis only and diabetic patients with periodontitis before and after non-surgical periodontal therapy.

Time frame: 3 months

clinical attachment level

estimation of clinical attachment level in patients with chronic periodontitis only and diabetic patients with periodontitis before and after non-surgical periodontal therapy.

Time frame: 3 months

Data from ClinicalTrials.gov

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