VEGF and PEDF in Patients With Myopic Choroidal Neovascularization

Inclusion Criteria: * pathologic myopia, defined as spherical equivalent \>6 diopters and axial length \>26 mm * posterior pole myopic retinal changes (posterior staphyloma, chorioretinal atrophy, papillary crescent); * fluorescein angiography, indocyanine green angiography and optical coherence tomography detection of the subfoveal or juxtafoveal choroidal neovascularization * clear ocular media; Exclusion Criteria: * previous treatment for choroidal neovascularization, including the previous intravitreal drug injection or PDT * presence of other maculopathy as diabetic retinopathy or retinal vascular occlusion * history of recent myocardial infarction or other thromboembolic events * ongoing uncontrolled hypertension or glaucoma * refractive media opacities * previous eye surgery