Oral Auranofin for Reduction of Latent Viral Reservoir in Patients With HIV Infection

Inclusion Criteria: * Participant is willing and able to give informed consent for participation in the study. * Male or female, between 18 and 55 years of age. * Stable dose of ART (defined as at least 2 nucleoside/nucleotide reverse transcriptase inhibitors plus a non-nucleoside reverse transcriptase inhibitor, integrase inhibitor, or a protease inhibitor) for at least 2 years from study consent and with no modifications expected during the study. * HIV plasma viral load \<50 copies/ml for at least 3 years with several measurements per year and most recent viral load within 3 months of screening.8 * No previous failure of ART, understood as a rebound in viral load that can be detected after having reached undetectable levels. Low-grade increases (\<200 copies of HIV RNA/mL) and transitory increases (blips) resolved without modifying ART are acceptable. * Did not experience AIDS defining event * Two CD4+ T cell counts greater than 500 cell/µl in the six months prior to screening * Able (in the Investigators' opinion) and willing to comply with all study requirements. Exclusion Criteria: * Contraindication to auranofin therapy, including congestive heart failure, renal dysfunction, history of blood dyscrasias; History of gold induced disorders (e.g. necrotising enterocolitis, pulmonary fibrosis, exfoliative dermatitis, bone marrow aplasia or other sever hematologic disorders), porphyria; History of severe allergic or anaphylactic reactions or hypersensitivity to auranofin or other gold compounds. * Treatment with nucleoside/nucleotide analogs with higher risk of mitochondrial toxicity: zidovudine (ZDV), Stavudine (d4T), didanosine (ddI), di-deoxy-cytidine (ddC) or abacavir (ABC). * Presence of clinically significant skin/mucosal disease such as hives or dermatitis, pruritus or rash, eczema, stomatitis or conjunctivitis * Significant acute medical illness in the past 4 weeks * Inflammatory bowel disease, Crohn's disease or ulcerative colitis * Current or recent (i.e. within 2 weeks) gastrointestinal disease or GI disturbances, including vomiting, abdominal pain, diarrhea, which may impact the absorption of the investigational drug * History of gastrointestinal surgery that could impact upon the absorption of Auranofin * Scheduled elective surgery or other procedures requiring general anesthesia during the study * Participant has the following laboratory values within 2 weeks before starting the investigational drug (laboratory tests may be repeated, as clinically indicated, to obtain acceptable values before failure at screening is concluded) * Known hepatitis B or C infection as indicated by the presence of Hepatitis B surface antigen (HBsAg) or hepatitis C virus RNA (HCV-RNA) in blood * Receipt of immunomodulating therapy, EPO or G-CSF, immunization or systemic chemotherapeutic agents within 12 weeks prior to study entry * Anticipated requirement for treatment with drugs that may interfere with auranofin as outlined in Appendix 7. * Receipt of RBC or platelet transfusion or receipt of cell product within 24 weeks prior to study entry * Insulin dependent diabetes * Systemic Lupus Erythematosus (SLE) * Current or history of seizure disorder * Previous diagnosis of lymphoma or other HIV related cancers. * Any other significant disease or disorder (including psychiatric disorders) which, in the opinion of the Investigator, may either put the participants at risk because of participation in the study, or may influence the result of the study, or the participant's ability to participate in the study. * Women who are pregnant or breastfeeding, or with a positive pregnancy test during screening or Women of Child Bearing Potential (WOCBP) who are unwilling or unable to use an acceptable method of contraception to avoid pregnancy for the entire study period and for at least 4 weeks before and 24 weeks after study treatment * Males or females who are unwilling or unable to use barrier contraception during sexual intercourse for the entire study period, including at least 4 weeks before, 4 weeks after study treatment, and when plasma HIV-RNA is detectable using standard assays * Subjects who have participated in another research study involving an investigational product in the past 12 weeks.