Dose Tolerance Study After Ocular Administration of Tiotropium in Healthy Male Volunteers

Inclusion Criteria: * Healthy males * Age range from 21 to 50 years * Within ± 20% of normal weight (Broca-Index) * Written informed consent given Exclusion Criteria: * Results of the medical examinations or laboratory tests are judged by the clinical investigator to differ significantly from normal clinical values * Volunteers with known gastrointestinal, hepatic, renal, respiratory, cardiovascular, metabolic, immunological or hormonal disorders * Volunteers with disease of the central nervous system (such as epilepsy) or with psychiatric disorders * Volunteers with known history of orthostatic hypotension, fainting spells or blackouts * Volunteers with chronic or relevant acute infections * Volunteers with history of allergy/ hypersensitivity (including drug allergy) * Volunteers with known eye diseases (incl. glaucoma), with hyperopia (\> 3 diopters) or with contact lenses * Volunteers with intraocular pressure \> 22 mmHg * Volunteers with predisposition to narrow-angle glaucoma * Volunteers with disturbed micturition * Volunteers who have taken a drug with a long half-life (≥ 24 hours) within ten half-lives of the respective drug before enrolment in the study * Volunteers who received any other drugs which might influence the results of the trial during the week previous the start of the study * Volunteers who have participated in another study with an investigational drug within the last two months preceding this study * Volunteers who smoke (\> 10 cigarettes or 3 cigars or 3 pipes/day) * Volunteers who are not able to refrain from smoking on study day * Volunteers who drink more than 40 g of alcohol per day * Volunteers who are dependent on drugs * Volunteers who have donated blood (≥ 100 ml) within the last four weeks * Volunteers who participated in excessive physical activities (e.g. competitive sports) within the last week before the study