Can Brief High-intensity Interval Training Mitigate the Adverse Consequences of High-fat Overfeeding?

University of Adelaide7 enrolled

Overview

Previous research has shown that indulging in 50% more calories than required for as little as 3 days can significantly impact markers of metabolic health in lean and overweight individuals. Here, the investigators will determine if 3 brief sessions of high-intensity interval training can mitigate the adverse consequences of 7 days high-fat overfeeding in sedentary, overweight males.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Enrollment

Conditions

Insulin Resistance

Interventions

Wingate HITOTHER

3 sessions of Wingate based High-Intensity Interval Training (6-8 x 15 second "all out" sprints on a cycle ergometer interspersed by 2 minutes recovery)

Modified HITOTHER

3 sessions of Modified High-Intensity Interval Training (8 x 60 second sprints at approximately 90-95% VO2 peak on a cycle ergometer interspersed by 60 seconds recovery)

High-fat overfeedingOTHER

7 days of high-fat overfeeding (50% excess calories)

Eligibility

Sex: MALEMin age: 18 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Sedentary (no more than 2 sessions of structured moderate intensity aerobic exercise or resistance training per week) * Overweight (BMI 25-29.9 kg/m2) Exclusion Criteria: * Personal history of any major illness (i.e. cardiovascular disease, diabetes, hypertension, cancer, renal/liver impairments, major psychiatric disorders, eating disorders etc.) * History of chest pain (either at rest or during exercise.) * Abnormal resting ECG at screening visit * Chronic use of any prescribed or non-prescribed medications (i.e. anti-hypertensive, statins, metformin, anti-inflammatories, antidepressants etc.) * Blood pressure or blood lipids outside of reference ranges * Serum ferritin \<30ng/mL * Uncontrolled asthma, current fever, or upper respiratory infection * Current intake of \> 140g alcohol/week * Current smokers of cigarettes/cigars/marijuana * Current intake of any illicit substance * Experience claustrophobia in confined spaces * Donated blood in the past 3 months * Migraines * Unable to comprehend study protocol * Unable to perform exercise on a cycle ergometer at second screening visit

Locations (1)

South Australian Health & Medical Research Institute

Adelaide, South Australia, Australia

Outcomes

Primary Outcomes

Change in glucose metabolism

Changes in insulin and glucose area under the curve assessed via 75g Oral Glucose Tolerance Test.

Time frame: 1 week

Secondary Outcomes

Change in plasma levels of cytokines

Change in plasma levels of adiponectin, irisin, sex hormone-binding globulin and c-reactive protein

Time frame: 1 week

Data from ClinicalTrials.gov

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