Magnetic Resonance Imaging in Myocarditis

Heart Center Leipzig - University Hospital129 enrolled

Overview

The purpose of this study is the assess the diagnostic performance of magnetic resonance imaging in patients with suspected myocarditis by applying different imaging sequences at different MR scanners

In patients with clinical suspicion of myocarditis biventricular endomyocardial biopsy is performed for definite diagnosis. In addition, patients undergo magnetic resonance imaging at 1.5 Tesla and 3.0 Tesla within 24 hours. The imaging protocol of both scan include assessment of myocardial edema respectively edema ratio; myocardial hyperemia respectively global relative enhancement (gRE); myocardial fibrosis/necrosis respectively myocardial LE and T1 and T2 mapping sentences. Diagnostic performance of different imaging protocols as compared to the findings of endomyocardial biopsies is calculated. The protocol also includes a follow-up MR can at 3 months.

Study Type

OBSERVATIONAL

Enrollment

129

Conditions

Myocarditis

Interventions

Endomyocardial BiopsyOTHER

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: Symptoms such as: * Dyspnea or Orthopnea or * Palpitations or * Exercise intolerance or * Angina Evidence of myocardial involvement: * ventricular dysfunction on echocardiography or * new or persistent ECG changes * elevated Troponin T History of viral infection Exclusion Criteria: * Contraindication for magnetic resonance imaging * Impaired renal function: glomerular filtration rate ≤ 30 ml/min/m2 * Patients presenting with pregnancy * Patients without informed consent * Participation in another trial.

Locations (1)

Heart Center of the University Leipzig

Leipzig, Germany

Outcomes

Primary Outcomes

Accuracy, sensitivity and specificity of magnetic resonance imaging sequences

The diagnostic accuracy of individual and a combination of MR imaging sequences (late enhancement images, assessment of global edema, relative enhancement and T1 and T2 mapping sequences) will be determined by comparison to endomyocardial biopsies, which serve as diagnostic gold-standard

Time frame: baseline

Secondary Outcomes

Diagnostic performance of biventricular endomyocardial biopsies

Time frame: baseline

Data from ClinicalTrials.gov

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