Effect of Interventions on the Progression of Knee Osteoarthritis

Inclusion Criteria: * Patients of either sex aged between 40 to 65 years with mild to moderate osteoarthritis of the knees. * Patients should have history of knee pain for at least 6 months and on the majority of days during the preceding month * Each joint will be scored separately so one patient with bilateral knee osteoarthritis will be counted as 2 knees. * The osteoarthritis will be graded on basis of clinical score as well as seen on appropriately positioned x rays using the Kellgren and Lawrence grading. (Tibio femoral osteophytes of at least 1 mm, Kellgren Lawrence grading of 2 or 3) * Patients with diabetes are sent to the diabetes clinic and are included once their HbA1c level becomes normal. * Patients giving Informed consent Exclusion Criteria: * Patients with severe end stage tricompartmental osteoarthritis of the knees . * Presence of uncontrolled systemic disease like chronic liver and renal disease * Patients with diagnosis other than osteoarthritis, such as knee arthritis due to rheumatoid disease, gout, post traumatic arthritis * Patients with history of surgery to any knee will have that knee excluded * Pregnant or lactating mothers * Patients with chronic anaemia * Patients who get an injection in their affected knee