This is a double-blind randomized clinical trial which will start at June 2014 and end on June 2015 in Isfahan city. Serum insulin level is considered as a key variable and the sample size calculated 70 persons (35 persons for control group and 35 persons for patient group). Patient group will receive magnesium supplement (250 milligram) and the other group will receive placebo which is similar to the magnesium tablets in color, odor and appearance both for 8 weeks. All subjects will complete 4 physical activity and 4 dietary records. Outcome measurements including sex hormone levels, metabolic and inflammatory profiles will be measured at the beginning and end of the study as well as anthropetric measurements.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
70
This is a double-blind randomized clinical trial which will be started at June 2014 and end on June 2015 in Isfahan city. Serum insulin level is considered as a key variable and the sample size was calculated to be 70 persons (35 persons for control group and 35 persons for patient group). Patient group will receive magnesium supplement (250 milligram) and the other group will receive placebo which is similar to the magnesium tablets in color, odor and appearance both for 8 weeks. All subjects will complete 4 physical activity and 4 dietary records. Outcome measurements including metabolic and inflammatory profiles,sex hormone levels will be measured at the beginning and end of the study as well as anthropometric measurements.
Isfahan University of Medical Sciences
Isfahan, Isfahan, Iran
RECRUITINGSerum insulin level
Time frame: 8 Weeks
Insulin Resistance
Time frame: 8 weeks
Fasting Blood Sugar
Time frame: 8 weeks
Quantitative insulin sensitivity check index (Quicki)
Time frame: 8 weeks
HOMA-IR
Time frame: 8 weeks
HOMA-B
Time frame: 8 weeks
High Density Lipoprotein
Time frame: 8 weeks
Low Density Lipoprotein
Time frame: 8 weeks
Triglyceride
Time frame: 8 weeks
Total Cholesterol
Time frame: 8 weeks
Androgen
Time frame: 8 weeks
Testosterone
Time frame: 8 weeks
C-Reactive Protein
Time frame: 8 weeks
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