Predicting Normal vs. Carrier Status in Euploid Embryos of Translocation Carriers

Reproductive Medicine Associates of New Jersey11 enrolled

Overview

The purpose of this study is to assess the accuracy of predicting the normal or carrier status of human embryos resulting from in vitro-fertilization (IVF) from patients carrying a balanced translocation.

This study aims to evaluate the validity of using informative SNPs to distinguish balanced from normal embryos. This will involve acquiring material from families to set phase for informative SNPs, evaluation of existing and new embryo SNP array data, and follow up analysis of children born after applying the procedure.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Balanced Chromosomal Translocation

Eligibility

Sex: ALLMin age: 7 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * patients with balanced translocations who have undergone IVF Exclusion Criteria: * those who do not wish to know their child(s) karyotype

Locations (1)

Reproductive Medicine Associates of New Jersey

Basking Ridge, New Jersey, United States

Outcomes

Primary Outcomes

Proportion of correct predictions of normal vs. balanced ploidy status as compared to conventional karyotype

Time frame: up to 12 months once pregnant

Data from ClinicalTrials.gov

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