Evaluation of the Effect of Hydration About Orthostatic Hypotension in the Elderly. Difference With Venous Compression

Central Hospital, Nancy, France110 enrolled

Overview

Primary objective: To compare the decrease in systolic blood pressure between hydration and venous contention when switching to a standing position. Hypothesis in that hydration is better than venous contention. Secondary objective: To evaluate the effect of hydration on lowering systolic blood pressure during the passage standing in elderly patients with orthostatic hypotension. Inclusion criteria: Patient aged over 75 years old with orthostatic hypotension proved to 1 and / or 3 min

Day 0: confirmation of the orthostatic hypotension, without prevented measures Two groups randomized : * Group 1: First day (day 1), Orthostatic Hypotension test after hydration by three large glasses of clear liquid (33cl). Second day (day 2), Orthostatic Hypotension test with venous contention in the morning. * Group 2: First day (day 1), Orthostatic Hypotension test after implementation of venous contention in the morning. Second day (day 2), Orthostatic Hypotension after hydration by three large glasses of clear liquid (33cl).

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Enrollment

110

Conditions

Orthostatic Hypotension

Interventions

HydrationOTHER

Hydratation the first day in the arm 1 Hydration the second day in the arm 2

Venous contentionOTHER

Venous contention the second day in the arm 1 Venous contention the first day in the arm 2

Eligibility

Sex: ALLMin age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patient aged 75 and older with orthostatic hypotension proved to 1 and / or 3 minutes. * Written consent of the subject * Hospitalization or stay expected minimum 3 days * Affiliation to a social security scheme Exclusion Criteria: * bedridden patient or without possibility of verticalization * Patient who can't stand up (pulmonary embolism with high risk) * Patient who refuse to participate in the study * Patient with legal protection * State or condition that may affect the stability of blood pressure during the study (hyperthermia, modification antihypertensive treatments less than 48 hours before inclusion...) * Pathology preventing hydration: Heart failure with less than 1 Liter water restriction, swallowing disorders preventing hydration orally, inability to nutrition and hydration orally * Intravenous or subcutaneous hydration (intravenous or subcutaneous treatments not included) * Patient who can't have venous contention: Blue phlebitis, septic thrombosis, arteritis with score less than 0.6, varicose ulcers during treatment

Locations (2)

Centre Hospitalier Régional Universitaire de Nancy

Nancy, France

RECRUITING

Maison Hospitalière Saint Charles

Nancy, France

RECRUITING

Outcomes

Primary Outcomes

difference in systolic blood pressure between sitting and standing at 1 and 3 minutes between hypotension test with hydration and hypotension test with venous contention

Time frame: during 3 days: day 0, day 1, day 2

Secondary Outcomes

difference in systolic blood pressure between sitting and standing at 1 and 3 minutes between hypotension test with hydration and hypotension test without prevention

Time frame: during 3 days: at day 0, day 1, day 2

Central Contacts

Athanase Benetos, Pr

CONTACT

0383153322 a.benetos@chu-nancy.fr

Marion Serot Gresser

CONTACT

0664524831 mariongresser@hotmail.fr

Data from ClinicalTrials.gov

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