Preterm neonates are fragile to infections. Their immune system is immature, yet in France, primary vaccines are injected at two months of age, as in term infants. Recommendations for vaccinations in infants have changed in France in 2013, suppressing the second injection at three months after birth. Preterm and full-term born infants are now vaccinated at two and four months of age, but no data regarding efficacy in very preterm infants have been registered. The investigators hypothesize that two vaccine injections (at two and four months) would be less efficient than three injections (two, three and four months) in very preterm-born infants.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
160
DTP-pertussis-Hib injections at two, three, four months after birth
DTP-pertussis-Hib injections are administered at two and four months after birth
Centre Hospitalier Regional et Universitaire, Maternite Regionale
Nancy, France
Centre Hospitalier de Thionville
Thionville, France
Hib antibody dosage in blood sample
Time frame: 5 months after birth
Pertussis antibody dosage in blood sample
Time frame: 5 months after birth
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