Gut Microbiota in Obesity and Diabetes

Gulhane School of Medicine81 enrolled

Overview

An altered gut microbiota composition has recently been linked to obesity and diabetes. The principal aim of this study was to investigate and compare the gut microbiota composition of obese, diabetic and control individuals. Then, associations between analyzed gut microbial concentrations and clinical-biochemical blood parameters were assessed.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Obesity Type 2 Diabetes Mellitus

Interventions

Comparison of the gut microbiota compositionOTHER

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Subjects with obesity or newly diagnosed type 2 diabetes * 18 years to 65 years of age Exclusion Criteria: * Any chronic disease (other than obesity and diabetes) * Alcohol consumption/smoking * Pregnancy/breastfeeding * The use of antibiotics, pro-prebiotics within 3 months * \<18 years or \>65 years * History of intestinal surgery

Locations (1)

Department of Endocrinology and Metabolism, Gulhane School of Medicine

Ankara, Turkey (Türkiye)

Outcomes

Primary Outcomes

The comparison of the gut microbiota composition

The gut microbiota composition of obese, diabetic and control individuals was analyzed by quantitative real-time PCR (qRT-PCR)

Time frame: 9 months

Secondary Outcomes

The relationship between metabolic parameters and the gut microbiota composition

A multivariate linear regression analysis was performed in order to test associations between the gut microbiota composition and metabolic variables of participants

Time frame: 9 months

Data from ClinicalTrials.gov

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