The study object is to demonstrate the usefulness and safety of lipiodol localization technique for individuals undergoing ground-glass opacity (GGO) Video-assisted thoracic surgery (VATS) resection compared to hook wire localization technique. A total of 250 participants will be enrolled in a 1:1 fashion to Lipiodol or Hook-wire groups. If the aims of this study are achieved, the use of lipiodol localization technique will be widespread their application for localization of non-palpable pulmonary lesions that are indicated for VATS resection.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
250
Yonsei University Health System, Severance Hospital
Seoul, South Korea
Procedure success rate
Procedure success was defined as marking (lipiodol or hook-wire) the GGO lesion within 1 cm without pleural leakage of lipiodol or dislodgement of the hook-wire.
Time frame: one day
Complication rate
Procedure-related complications such as pneumothorax, lung hemorrhage, hemoptysis, air-embolism and death
Time frame: one day
Procedure time
Total procedure time for lung localization
Time frame: 1 hour
Surgery time
Surgery time for obtaining wedge resection specimen
Time frame: 12 hours
Safety resection margin
The safety specimen resection margin was categorized either as positive (grossly positive (R2), microscopically positive if tumor was at the inked surface (R1)), or negative (microscopically negative if there was no tumor at the inked surface (R0))
Time frame: 1 hour
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