1\. Neuropathic pain in spinal cord injured patients 1. Inclusion criteria * pain intensity, visual analogue scale \> 3 * a LANSS (Leeds assessment of neuropathic symptoms and signs) score of 12 and above * aged ≥20 2. Method * Stop pain medications * Test oxcarbazepine (150mg twice daily) and pregabalin (150mg twice daily) * Check pain intensity (VAS score) with Baron's classification
In the present study, pharmacologic treatment included pregabalin and oxcarbazepine. Stop medications such as Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), tramadol and anti-spastic drugs (baclofen, tizanidine) and other medications known to have effect on pain and the central nervous system prior to the study for at least 3 days. 1. Pain intensity (VAS score) 1. 4 spontaneous characters * electric * burning * pricking * numbness 2. evoked pain * allodynia * heat hyperalgesia * pressure hyperalgesia 2. Location of neuropathic pain 1. neuropathic pain at level of spinal cord injury 2. neuropathic pain below level of spinal cord injury 2\. Side effects
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
63
Subjects will take pregabalin for the duration of 2 weeks. The dosage will be increased from 75 mg twice to 150 mg twice a day. Subjects will stop pregabalin for 1 week and take oxcarbazepine 150mg twice.
CHA University
Seongnam-si, Kyounggi-do, South Korea
Symptom based treatment of neuropathic pain
Pain intensity using Visual analogue scale (0\~100)
Time frame: 2 week later
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