Multiple Doses of BI 207127 NA, BI 201335 NA Followed by the Combination of BI 207127 NA and BI 201335 NA in Healthy Male Volunteers

Inclusion Criteria: * Healthy males (caucasian) * Age ranging ≥ 21 and ≤ 50 years * Body mass index (BMI) ≥ 19 and ≤ 29.9 kg/m2 * Willing to complete all study-related activities * Volunteers give their written informed consent prior to admission to the study Exclusion criteria: * Any finding of the medical examination (including blood pressure, pulse rate and electrocardiogram) deviating from normal and of clinical relevance * Gastrointestinal, hepatic, renal, respiratory, cardiovascular, metabolic, immunological or hormonal disorders, clinically relevant electrolyte disturbances * Diseases of the central nervous system (such as epilepsy) or psychiatric disorders or neurological disorders * History of photosensitivity or recurrent rash * History of orthostatic hypotension, fainting spells or blackouts * Chronic or clinically relevant acute infections * History of allergy/hypersensitivity (including drug allergy) which is deemed relevant to the trial as judged by the investigator * Intake of drugs with a long half-life (\> 24:00 hours) within at least one month or less than ten half-lives of the respective drug before enrolment in the study or during the study * Use of any drugs which might influence the results of the trial up to 7 days prior to enrolment in the trial or during the trial * vulnerable subjects (that is persons kept in detention) * exclusion of contraindications or hypersensitivity to midazolam and / or tolbutamide * Participation in another trial with an investigational drug (within two months prior to administration or during the trial) * Smoker (\> 10 cigarettes or \> 3 cigars of \> 3 pipes/day) * Inability to refrain from smoking on trial days * Alcohol abuse (\> 60 g/day) * Drug abuse * Blood donation (\> 100 mL within four weeks prior to administration or during the trial) * Any laboratory value outside the reference range if indicative of underlying disease or poor health * Excessive physical activities within the last week before the trial or during the trial * Hypersensitivity to treatment medication and/or related drugs of these classes * A marked baseline prolongation of QT/QTc interval (e.g., repeated demonstration of a QTcF, or QTcB interval \>450 ms) * Homozygous carriers of the UGT1A1 (uridine diphosphate glucuronosyltransferase 1A1) enzyme polymorphism \*28 and \*60