Safety and Efficacy of Berodual® Inhaled Via Respimat® Compared to MDI (Metered Dose Inhaler) in Pediatric Patients With Asthma

Inclusion Criteria: * Diagnosis of bronchial asthma according to the ATS (American Thoracic Society) criteria * Male or female children between 6 and 15 years old * Screening FEV1: 60-90 % of predicted normal. Predicted normal values will be based on the reference values by Cotes * Airway obstruction reversibility: FEV1 should increase ≥ 12% over baseline 30 to 60 minutes after administration of 2 puffs from the Berodual® MDI used with the Aerochamber® * Ability to be trained in proper use of MDI with Aerochamber® and Respimat® * Ability to perform technically satisfactory pulmonary function tests * No hospital admission for an exacerbation and stable dosage of all pulmonary medication in the last four weeks * Parent(s)/legal guardian is able and willing to give written informed consent in accordance with Good Clinical Practice (GCP) and local legislation. The child is willing to give oral consent Exclusion Criteria: * Patients with significant disease other than asthma, e.g. history of clinically significant cardiovascular, renal, neurological, hepatic or endocrine dysfunction (e.g. hyperthyreosis). A clinically significant disease is defined as a disease which in the opinion of the investigator may either put the patient at risk because of participation in the study or which may influence the results of the study or the ability of the patient to participate in and complete the study * Tuberculosis with indication for treatment * History of cancer within the last five years * Patients who have undergone thoracotomy * Current psychiatric disorders * History of life threatening pulmonary obstruction, active bronchiectasis, lung fibrosis, AIDS (acquired immunity deficiency syndrome) and cystic fibrosis * Severe bronchial asthma with frequent nocturnal asthma attacks or acute exacerbations induced by recurrent bronchial infections several times per year * An upper or lower respiratory tract infection in the four weeks prior to the screening visit (= Visit 1) or during the 2-week run-in period * Patients with known narrow-angle glaucoma or raised intra-ocular pressure * Patients with known intolerance or hypersensitivity to any of the trial medication including excipients * Patients using oral corticosteroid medication within the last 4 weeks * Patients using leukotriene receptor antagonists and 5-LO (lipoxygenase) inhibitors within the last 4 weeks * Beta-blocker medication * Patients who have taken an investigational drug one month or six half-lives (whichever is greater) prior to the screening visit * Previous participation in the run-in phase of this study * Presence of psycho-social factors in the patient and/or relatives which, at the discretion of the investigator, do not assure compliance with medication, procedures and/or protocol