This research through using bispectral index to guide the induced dose and speed of etomidate lipid emulsion for pediatric total venous anesthesia,and to provide a reference for clinical anesthesia physician.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
120
1. intravenous injection midazolam 0.08 mg/kg, fentanyl 0.002 mg/kg, cisatracurium 0.15 mg/kg for induction of anesthesia. 2. infusion of etomidate at 2 minutes before anesthesia induction
1. intravenous injection midazolam 0.08 mg/kg, fentanyl 0.002 mg/kg, cisatracurium 0.15 mg/kg for induction of anesthesia. 2. infusion of propofol at 2 minutes before anesthesia induction
1. intravenous injection midazolam 0.08 mg/kg, fentanyl 0.002 mg/kg, cisatracurium 0.15 mg/kg for induction of anesthesia. 2. inhale sevoflurane for anesthesia induction and maintenance
the amount of drugs
the amount of etomidate,propofol and sevoflurane used in anesthesia induction
Time frame: from the beginning of induction to Bispectral Index < 50,up to 5 minutes
the drugs used time
the injection time of etomidate and propofol, and the inhale time of sevoflurane during anesthesia induction
Time frame: from the beginning of induction to Bispectral Index < 50,expected to be within 1 minute
numbers of muscular fibrillation
numbers of muscular fibrillation in anesthesia induction
Time frame: from the beginning of induction to Bispectral Index < 50,up to 5 minutes
degree of inflammation reaction
serum levels of interleukin 6 and tumor necrosis factor α will be measured at each time point using ELISA method
Time frame: baseline,5 minutes after indution,5 minutes before operation end,30 mimutes、24h and 48h after operation
adrenal function
serum level of cortisol will be measured at each time point using radioimmunoassay
Time frame: baseline,5 minutes after indution,5 minutes before operation end,30 mimutes、24h and 48h after operation
hemodynamic parameters
heart rate,blood pressure,electrocardiogram and pulse oxygen saturation recorded at 4 time points including before anesthesia induction,before endotracheal intubation,after endotracheal intubation and after operation immediately
Time frame: from the beginning of induction to skin closure, up to 3 hours
sedation degree
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Bispectral index,train-of-four stimulation and the temperature recorded at 4 time points including before anesthesia induction,before endotracheal intubation,after endotracheal intubation and after operation immediately
Time frame: from the beginning of induction to skin closure, up to 3 hours