This prospective cohort study aims to determine if apparently healthy children with no significant co-morbidities who undergo general anaesthesia for minor surgery before 15 months of age will develop measurable deficits in neurocognitive development compared to apparently healthy children with no significant co-morbidities who do not undergo general anaesthesia or surgery.
We hypothesize that healthy children exposed to general anaesthesia for minor surgery before 15 months of age will have significantly lower neurocognitive scores at 6,18, 24 and 36 months of age compared with age, and gender matched healthy children from the GUSTO cohort without prior exposure to general anaesthesia or surgery. (GUSTO: Growing Up Towards Healthy Outcomes in Singapore: a prospective longitudinal study providing normative data from the local population).
Study Type
OBSERVATIONAL
Enrollment
250
Singapore Institute of Clinical Sciences
Singapore, Singapore
KK Women's and Children's Hospital. 100 Bukit Timah Road
Singapore, Singapore
Neurocognitive Assessment: Bayley's Scale of Infant Development-III
Bayley's Scale of Infant Development-III
Time frame: 24 months of age
Neurocognitive Assessment: Deferred Imitation
Deferred imitation is used to assess declarative memory
Time frame: 6 and 18 months of age
Neurocognitive Assessment: Habituation
Determines if an infant shows 'novelty preference' when stimuli are shown repeatedly.
Time frame: 6 and 18 months of age
Behavioural Assessment: Child behaviour checklist
Time frame: 24 months of age
Event Related Potential
Auditory Oddball
Time frame: 6 and 18 months of age
Visual Expectation
Time frame: 6 and 18 months of age
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