Respiratory Kinematics of Cough in Healthy Older Adults and Parkinson's Disease

University of Florida44 enrolled

Overview

The purpose of this research study is to test cough function in individuals with Parkinson's disease and healthy older adults. Cough is a complex, defensive function which involves movement of the chest and lungs. The investigators want to compare the movement of the chest wall and the lungs during voluntary and reflex cough. The long-term goal of this research is to develop treatments for people with cough dysfunction. Cough dysfunction increases the risk for respiratory infections such as pneumonia. The results from this study will provide information to help researchers understand the difference between reflex and voluntary cough more fully.

If the participant agrees to participate, the investigators will first test pulmonary (lung) function. Next, the investigators will test voluntary and reflex cough. After this first round of cough testing, the investigators will ask participants to cough long and hard during voluntary and reflex cough testing. Finally, the investigators will view the larynx (voice box) with an endoscopic camera inserted through the nose. This test is done to see if there are any changes in the larynx that may influence cough.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Cough Parkinson's Disease

Interventions

CapsaicinDRUG

For reflex cough testing, all participants will receive various concentrations of nebulized capsaicin. Delivery of multiple concentrations and doses of capsaicin allows for accurate assessment of both the strength (airflow measures) of reflex, as well as cough sensitivity.

Voluntary cough testOTHER

Participants will be fitted with a facemask covering their mouth and nose, and instructed to cough into the facemask.

Eligibility

Sex: ALLMin age: 55 YearsMax age: 85 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Age 55-85 years * Ability to provide informed consent For participants with Parkinson's disease (PD): \- Diagnosis of PD (Hoehn \& Yahr stages II-IV) by a University of Florida Movement Disorders fellowship trained neurologist having completed a clinical assessment of each participant's PD severity and arriving at the diagnosis of PD by applying strict United Kingdom brain bank criteria. Exclusion Criteria: Participants with PD: \- History of neurological disorders other than PD (e.g. multiple sclerosis, stroke, brain tumor, etc) Healthy older adults: * History of neurological disease including PD * History of head and neck cancer * History of breathing disorders or disease (i.e. chronic obstructive pulmonary disease, asthma) * History of smoking for more than 5 years at any one time (as this reduces the sensitivity to capsaicin) * History of chest infection the last 5 weeks * Failure of a screening test of pulmonary function (e.g. forced expiratory volume in one second/forced vital capacity\<75%) * Difficulty complying due to neuropsychological dysfunction (i.e. severe depression)

Respiratory Kinematics of Cough in Healthy Older Adults and Parkinson's Disease

Overview

Conditions

Interventions

Eligibility

Locations (2)

Outcomes

Primary Outcomes