The purpose of this research project is to assess the effectiveness of intra-articular injections of autologous platelet-rich plasma (PRP) after arthroscopic microfracture. Our hypothesis is that platelet-rich plasma will improve patient's clinical outcomes and chondral healing following microfracture performed during femoroacetabular impingement (FAI) hip arthroscopy.
The purpose of this research project is to assess the effectiveness of intra-articular injections of autologous platelet-rich plasma (PRP) after arthroscopic microfracture. Our hypothesis is that platelet-rich plasma will improve patient's clinical outcomes and chondral healing following microfracture performed during femoroacetabular impingement (FAI) hip arthroscopy. This study has two aims: 1. Evaluate clinical efficacy of intra-articular injections of platelet-rich plasma (PRP) following arthroscopic microfracture. 2. Evaluate if microfracture followed by PRP injections improves chondral healing. Microfracture has shown good results with chondral lesions of the hip. However, microfracture does not regenerate normal hyaline cartilage. There is growing evidence that PRP can improve articular cartilage healing. Injection of PRP following microfracture may help regeneration to normal hyaline like articular cartilage together with soft tissue healing, thereby improving patients' early and long-term outcomes of chondral healing. Patients will be randomized to one of two study arms - microfracture with PRP (treatment arm) and microfracture with saline (control arm) in a 1:1 ratio.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
University of Colorado Denver, CU Sports Medicine
Boulder, Colorado, United States
MRI dGEMRIC
MRI dGEMRIC will be utilized to assess chondral healing. Change is being assessed between measurement time points.
Time frame: 12 and 24 months post-operative
PA Hip X-Ray
Change is being assessed between measurement time points.
Time frame: Baseline, 12 and 24 months post-operative
International Hip Outcome Tool (IHOT)
Patient reported outcomes assessed from patient completed surveys. Change is being assessed between measurement time points.
Time frame: Pre-operative; and 3, 6, 12, and 24 month post-operative
Western Ontario and McMaster (WOMAC) osteoarthritis index
Patient reported outcomes assessed with patient completed survey.Change is being assessed between measurement time points.
Time frame: Pre-operative; and 3, 6, 12, and 24 month post-operative
Non-arthritic hip score
Patient reported outcomes assessed with patient completed survey. Change is being assessed between measurement time points.
Time frame: Pre-operative; and 3, 6, 12, and 24 month post-operative
Range of Motion (ROM)
ROM assessed as part of clinical outcome physical exam. Change is being assessed between measurement time points.
Time frame: Pre-operative; prior to injections at week 1 and 2 post-operative; 6 week, and 3, 6, 12, and 24 months post-operative
Flexion Abduction and External Rotation (FABER)
FABER assessed as part of clinical outcome physical exam. Change is being assessed between measurement time points.
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Time frame: Pre-operative; prior to injections at week 1 and 2 post-operative; 6 week, and 3, 6, 12, and 24 months post-operative
Bicycle Kicks
Bicycle kicks assessed as part of clinical outcome physical exam. Change is being assessed between measurement time points.
Time frame: Pre-operative; prior to injections at week 1 and 2 post-operative; 6 week, and 3, 6, 12, and 24 months post-operative