Caffeine Disposition After Inhalation

University of Tennessee24 enrolled

Overview

The purpose of this study is to determine how fast caffeine gets into your body with a product called Aeroshot™. Aeroshot™ is a lipstick sized device that you slide open and then put your mouth over the opening and inhale. A fine powder containing 100 mg of caffeine is deposited on your tongue and the inside of your mouth. Caffeine will be absorbed through the membranes in your mouth or swallowed and then absorbed in your stomach. We will compare the absorption of caffeine after using the Aeroshot™ with the absorption after drinking an energy drink by taking 15 blood samples over 8 hours and measuring the caffeine levels in your blood. You will also be asked to fill out some scales to measure the effects you feel after the caffeine dose. We hypothesize that caffeine absorption after inhalation will be faster than after an energy drink.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Healthy

Interventions

Eligibility

Sex: ALLMin age: 21 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * healthy volunteer * non-smoker Exclusion Criteria: * Take chronic medication * Co-existing diseases * Platelet count less than 100,000/uL (per microliter) * Acute or chronic psychiatric condition * Consume more than 300 mg of caffeine per day * Participated in another study within last 30 days or donated blood in last 6 weeks

Outcomes

Primary Outcomes

Caffeine plasma concentration

These are the collection times of blood samples relative to when the caffeine dose was consumed.

Time frame: 0, 1, 2, 5, 10, 15, 20, 30, 40, 60 minutes and 2, 3, 4, 6, 8 hours

Secondary Outcomes

Caffeine effects

Subjects will complete seven analog scales to assess the effects that they feel after the caffeine dose.

Time frame: 0, 1, 2, 5, 10, 15, 20, 30, 40, 60 minutes, and 2, 3, 4, 6, 8 hours