Microflare Protocol in Poor Responders

Woman's Health University Hospital, Egypt145 enrolled

Overview

The effect of use of the microflare down regulation protocol on the outcome of the IVF/ICSI cycles in poor responders

The microflare as a method of down regulation protocol can be used to prepare the females suffering from poor ovarian reserve to undergo IVF/ICSI cycles. In this study we are trying to outline its effect on the clinical pregnancy rate as a main primary outcome, and to compare its use with the addition of growth hormone to the same protocol.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

145

Conditions

Female Infertility Due to Diminished Ovarian Reserve

Interventions

Growth hormone (Norditropin, Novo nordisk)DRUG

Growth hormone (Norditropin, Novo nordisk) was administrated on day 6 of HMG stimulation daily in a dose of 2.5 mg S.C. till the day of hCG administration.

Eligibility

Sex: FEMALEMin age: 20 YearsMax age: 45 Years

Medical Language ↔ Plain English

Inclusion Criteria: * females fulfilling the criteria of the ESHRE consensus 2011: At least two of the following three features must be present: (i) Advanced maternal age (≥40 years) or any other risk factor for POR; (ii) A previous POR (≤3 oocytes with a conventional stimulation protocol); (iii) An abnormal ovarian reserve test (i.e. AFC ,5-7 follicles or AMH ,0.5 -1.1 ng/ml). Exclusion Criteria: * women who suffer from any other cause of infertility other than poor ovarian reserve * refusal of the patient to consent for using her data in the study.

Locations (1)

Kasr el aini hospital

Cairo, Cairo Governorate, Egypt

Outcomes

Primary Outcomes

Clinical pregnancy rates

Time frame: 15 months

Data from ClinicalTrials.gov

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