Dosage Calculation for Vitamin D Treatment

Bispebjerg Hospital31 enrolled

Overview

Severe vitamin D deficiency can be treated with oral loading doses of cholecalciferol. Our objective was to determine how to calculate the quantity of cholecalciferol needed for supplementation by single algorithm, usable on a patient-to-patient basis. We've conducted two studies. Study 1 was done retroactively and included 88 patients treated for low vitamin D, 60 of those with a loading dose. The second study included 29 patients and aimed to test the validity of an algorithm based on data from study 1, which included patient BMI. Both studies used oral loading doses and daily supplementation of cholecalciferol.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Deficiency, Vitamin D Obesity

Interventions

CholecalciferolDRUG

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * severe hypovitaminosis D (25OH-vit.D \<25 nmol/L) Exclusion Criteria: * Malabsorption * Renal disease * Other treatment with vitamin D related products * Patients with a recent travel history with suspected increased sun exposure

Outcomes

Primary Outcomes

Change in baseline value of [25-OH-vitamin-D]

Time frame: 1 week, 3 weeks and 3 months

Data from ClinicalTrials.gov

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