Proof Of Concept : Immunogenicity and Safety of hepB Injection in the Dermis Using VAX-ID

Inclusion Criteria: * healthy adults, checked anamnestically (based on medical history) at entry of the study * 18-35 years * vaccination status: fully vaccinated against hepatitis B at least 5 years ago, with proof of vaccine response (to avoid non-response among the subjects). Subjects has to ask for a document of this proof at the service occupational medicine of the University of Antwerp. * capable of understanding, reading and writing Dutch Exclusion Criteria: * other vaccination(s) 4 weeks before study onset * pregnancy and lactation (women will be questioned during anamnesis) * plan to have other vaccination during the study period