Salivary Inflammatory Biomarkers: Predictors & Comparative Effects of Sonicare/Elite-Flexcare in Stages of Perio Disease

Inclusion Criteria: 1. adult males or females between the ages of 18 and 75 years (inclusive). 2. able and willing to follow study procedures and instructions. 3. read, understood and signed an informed consent form. 4. present with at least 8 teeth in the functional dentition with a minimum of 3 adjacent teeth with interproximal papilla in each posterior sextant that will have the stent. 5. be in good general health. 6. present with one of the following five categories to be considered for enrollment * BGI health (all PD\<3mm, BOP\<10%) * BGI-gingivitis (all PD≤3mm, BOP≥10%) * BGI-P1 (1+ site with PD\>3mm, BOP≤10%) * BGI-P2 (1+ site with PD\>3mm, BOP\>10% but BOP≤50%) * BGI-P3 (1+ site with PD\>3mm, BOP\>50%) Exclusion Criteria: 1. chronic disease with oral manifestations or active infectious diseases such as hepatitis, HIV or tuberculosis. 2. gross oral pathology. 3. treatment with antibiotics for any medical or dental condition within 1 month prior to the screening examination. 4. chronic treatment (i.e., two weeks or more) with any medication known to affect periodontal status (e.g., phenytoin, calcium antagonists, cyclosporin, anticoagulants, non-steroidal anti-inflammatory drugs, high dose aspirin such as \>100mg per day) within one month of the screening examination. 5. ongoing medications initiated less than three months prior to enrollment (i.e., medications for chronic medical conditions must be initiated at least three months prior to enrollment). 6. clinically significant organ disease including impaired renal function, and/or any bleeding disorder. 7. severe unrestored caries, or any condition that is likely to require antibiotic treatment during the study, including the need for prophylactic antibiotic. 8. use any tobacco products or who have used tobacco products within the previous six months of the screening examination. 9. pregnant, or expect to become pregnant within the next three months and individuals nursing. 10. dental appliances that will interfere with stent construction.