Pharmacokinetics of Simvastatin and Its Metabolite Simvastatin Acid With and Without Concomitant Administration of Telmisartan in Healthy Subjects

Inclusion Criteria: * Healthy subjects as determined by results of screening * Signed written informed consent in accordance with good clinical practice (GCP) and local legislation * Age ≥ 18 and ≤ 55 years * Broca ≥ -20 % and ≤ +20 % Exclusion Criteria: * Any findings of the medical examination (including blood pressure, pulse rate and ECG) deviating from normal and of clinical relevance * Gastrointestinal, hepatic, renal, respiratory, cardiovascular, metabolic, immunological or hormonal disorders * Surgery of the gastro-intestinal tract (except appendectomy) * Diseases of the central nervous system (such as epilepsy) or psychiatric disorders or neurological disorders * Supine blood pressure at screening of systolic ≤ 110 mmHg and diastolic ≤ 60 mmHg * History of orthostatic hypotension, fainting spells or blackouts * Chronic or relevant acute infection * History of allergy/hypersensitivity (including drug allergy) which is deemed relevant to the trial as judged by the investigator * Intake of drugs with a long half life (\> 24 hours) ≤ 1 month prior to administration or during the trial * Use of any drugs which might influence the results of the trial (≤ 10 days prior to administration or during the trial) * Participation in another trial with an investigational drug (30 days prior to administration or during the trial) * Smoker * Alcohol abuse (\> 60 g/day) * Drug abuse * Blood donation (≤ 1 month prior to administration or during the trial) * Excessive physical activities (≤ 5 days prior to administration or during the trial) * Any laboratory value outside the reference range of clinical relevance * Hypersensitivity to telmisartan and/or simvastatin and/or related classes of drugs For female subjects: * Pregnancy * Positive pregnancy test * No adequate contraception (e.g. sterilization, intrauterine device (IUD), oral contraceptives) * Inability to maintain this adequate contraception during the whole study period * Lactation period