The objective of this study was to investigate the influence of meloxicam on low dose aspirin induced inhibition of platelet aggregation and thromboxane B2, when meloxicam is given before aspirin.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
16
Arachidonic acid induced platelet aggregation
Time frame: up to day 11 (treatment 1), up to day 3 (treatment 2)
Collagen-induced Platelet Aggregation
Time frame: up to day 11 (treatment 1), up to day 3 (treatment 2)
Adenosine diphosphate (ADP) Induced Platelet Aggregation
Time frame: up to day 11 (treatment 1), up to day 3 (treatment 2)
Serum Thromboxane B2 production
Time frame: up to day 11 (treatment 1), up to day 3 (treatment 2)
Number of patients with adverse events
Time frame: up to 6 weeks
Number of patients with abnormal changes in laboratory parameters
Time frame: up to day 11 (treatment 1), up to day 3 (treatment 2)
Number of patients with abnormal changes in 12-lead electrocardiogram (ECG)
Time frame: Screening, 24 hours after the last Aspirin intake
Number of patients with clinically significant changes in vital signs
Time frame: Screening, 24 hours after the last Aspirin intake
Assessment of tolerability on a 4-point scale
Time frame: 24 hours after the last Aspirin intake
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