Impact of Muscle Fat Accumulation on the Genomic Profile of Skeletal Muscle in Older Adults

Purdue University11 enrolled

Overview

Subjects were asked to come to the Purdue facilities after an overnight fast on 2 different testing days for 2.5 hours each day. On one day the subjects participated in blood pressure and body weight measurements as well as a muscle biopsy from the thigh. On the second day the subjects underwent an MRI and MRS scan of the thigh and calf.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Intermuscular Adipose Tissue Quantification

Eligibility

Sex: ALLMin age: 60 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * 60-80 years old, men and women, normal body weight or obese, Exclusion Criteria: * Certain medical conditions could have placed them at risk

Locations (1)

Purdue University

West Lafayette, Indiana, United States

Outcomes

Primary Outcomes

MRI

To determine the within day reproducibility of MRI scans for intermuscular adipose tissue (IMAT) quantification in older men and women.

Time frame: 1 day

Secondary Outcomes

genomic profile

To examine the influence of IMAT accumulation on the genomic profile of skeletal muscle of normal weight or obese adults.

Time frame: 1 day

Data from ClinicalTrials.gov

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