The purpose of the study is to investigate phenoxymethylpenicillin (the v-penicillin) and trimethoprim's possible induction of oxidative stress in human cells. The induction is examined by comparing changes in oxidative stress in the treatment group with the change in a placebo group. The study is a randomized-based placebo-controlled study. Each treatment group consists of 30 healthy male volunteers who consume either v-penicillins, trimethoprim or placebo over 7 days. The induction of oxidative stress is measured by 8-oxoguanosine and 8-oxodeoxoguanosine, isolated from urine. A t-test will be performed to compare drug treatment with placebo. The results will be published.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
90
Penicillin V: 2 x 330mg tablets should be taken twice daily
Trimopan: 2 x 100mg tablets should be taken twice daily
Placebo: 2 tablets should be taken twice daily
Department of Clinical Pharmacology
Copenhagen, Denmark
Urinary excretion of 8-oxoguanosine (nmol/24h)
Time frame: Change from Baseline after seven days of treatment
Urinary excretion of 8-oxodeoxoguanosine (nmol/24h)
Time frame: Change from Baseline after seven days of treatment
Malondialdehyde
Time frame: At the screening visit and at the final visit
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