Effect of Cumulative Chloride Dose on Development of Acute Kidney Injury in Critically Ill Children

Stanford University

Overview

The investigators would like to investigate the effect of chloride dosing on the development of acute kidney injury in critically ill patients. The investigators hypothesis is that administering intravenous fluids with higher chloride content are more likely to lead to acute kidney injury.

Retrospective chart review from 2008-2012 evaluating chloride dosing and serum chloride levels and their effects on acute kidney injury in the pediatric ICU. Patients will be included for the first seven days of their PICU stay.

Study Type

OBSERVATIONAL

Conditions

Acute Kidney Injury

Eligibility

Sex: ALLMin age: 1 MonthMax age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * age less than 18 years * PICU admitting diagnosis of sepsis, respiratory failure, or hepatic failure. Exclusion Criteria: * hyponatremia or hypernatremia at PICU admission * preexisting diagnosis of End-stage renal disease or renal transplant * presence of neurologic comorbidities.

Locations (1)

Lucile Packard Children's Hospital

Palo Alto, California, United States

Outcomes

Primary Outcomes

Acute Kidney Injury

or sooner if death or discharged

Time frame: 7 days

Secondary Outcomes

PICU length of stay

Time frame: 7 days

Hospital length of stay

Time frame: 7 days

Number of ventilator days

Time frame: 7 days

Mortality

Time frame: 7 days

Data from ClinicalTrials.gov

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