This study will consist of 80 patients ages 18 to 50 at the Emory Orthopaedic and Spine Center who are undergoing Anterior Cruciate Ligament (ACL) reconstruction with a quadriceps tendon autograft or bone patellar tendon bone autograft by Dr. Karas or Dr. Xerogeanes. Patients will be randomized into treatment and control arms. The treatment arm will include 40 patients receiving liposomal bupivacaine intra-operatively in addition to the current standard pain control regimen. The control group will include 40 patients receiving the standard post-operative pain control regimen. Patients will be assessed to identify differences in post-operative pain, satisfaction, as well as concomitant pain medication use. Post-operative range of motion will also be assessed.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
50
For the treatment group a total of 40 cc consisting of 20 cc of 1.3% Exparel® and 20 cc of 0.5 % marcaine will be administered to the ACL harvest site, into the periosteum surrounding the distal tibial tunnel site, and in the proximity of the skin incisions. No infiltration of Exparel will be provided intra-articularly.
Emory University Orthopaedic and Spine Center
Atlanta, Georgia, United States
Change in Numerical Rating Scale (NRS) Pain Score
The numerical rating scale (NRS) pain score is a self-reported pain scale from 0 to 10 where zero is equal to "no pain" and ten is equal to "worst possible" pain. The score was recorded every 12 hours for up to 144 hours (six days) post-operatively.
Time frame: Day of Surgery, Post-Operative Day 6 (Up to 144 hours)
Change in Home Opioid Use
The difference in amount of Percocet (7.5/325 tablets) usage post-surgery.
Time frame: Day of Surgery, Post-Operative Day 6 (Up to 144 hours)
Difference in Time to First Opioid Use
The time difference in hours to first Percocet (7.5/325 tablets) usage post-surgery.
Time frame: Day of Surgery, Post-Operative Day 6 (Up to 144 hours)
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