Efficacy and Safety of Glycopyrrolate Bromide of COPD Patients

Inclusion Criteria: * Male and female adults (40 ≤ age ≤ 80 years) with a diagnosis of COPD * Current smokers or ex-smokers * A post-bronchodilator FEV1 \< 60% of the predicted normal value and a post-bronchodilator FEV1/FVC \< 0.7 * Positive response to the reversibility test at screening defined as change in FEV1 ≥ 5%. * BDI score ≤ 10 * Patients free of exacerbations for at least 1 month Exclusion Criteria: * Pregnant or lactating women * Diagnosis of asthma * Patients treated for exacerbations in the 4 weeks prior to screening visit * Patients treated with long-acting antihistamines unless taken at stable regimen at least 2 months prior to screening and to be maintained constant during the study or if taken as PRN * Patients requiring long term (at least 12 hours daily) oxygen therapy for chronic hypoxemia * Known respiratory disorders other than COPD * Patients who have clinically significant cardiovascular condition