To determine if non-operative management with antibiotics alone is a feasible treatment alternative for pediatric patients with uncomplicated acute appendicitis with an appendicolith identified on imaging.
This study is a prospective randomized clinical trial comparing non-operative management with antibiotics to urgent appendectomy in children (ages 7-17yrs) with acute appendicitis with the presence of an appendicolith. Enrolled participants were followed up to 1 year post-discharge to observe the rates of appendicitis recurrence as well as identify the number of patients with complicated appendicitis as determined by pathologic examination.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
14
Intravenous and oral antibiotics without surgery Piperacillin/Tazobactam and then Augmentin Cipro/Flagyl if Penicillin allergic
Nationwide Children's Hospital
Columbus, Ohio, United States
Number of Participants That Did Not Have an Appendectomy
Percentage of patients who were successfully managed nonoperatively with success defined as not undergoing appendectomy by one year after discharge
Time frame: 1 year
Number of Participants With Complicated Appendicitis
Percent of patients found to have complicated appendicitis (gangrenous or perforated) on pathologic examination.
Time frame: 1 year
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