In the present clinical study including chronic, aggressive periodontitis and healthy individuals, the investigators aimed to determine the RANKL, osteoprotegrin (OPG), Interleukin-1 (IL-1β), IL-10, IL-1β levels in gingival crevicular fluid(GCF) before and after surgical periodontal treatment and search out the relationship of clinical parameters with these cytokine levels.
Study Type
OBSERVATIONAL
Enrollment
65
Hacettepe University
Ankara, Turkey (Türkiye)
RANKL (pmol) level in GCF
Changes in RANKL levels 3 months after surgical periodontal treatment in Chronic and Aggressive periodontitis determined by ELISA
Time frame: Baseline-3 months
OPG level (pg) in GCF
Changes in OPG levels 3 months after surgical periodontal treatment in Chronic and Aggressive periodontitis determined by ELISA
Time frame: Baseline-3 months
RANKL/OPG ratio
RANKL/OPG ratio changes 3 months after surgical periodontal treatment in Chronic and Aggressive periodontitis
Time frame: Baseline - 3months
IL-1β (pg) levels in GCF
Changes in IL-1β levels (determined by ELISA) 3 months after surgical periodontal treatment in Chronic and Aggressive Periodontitis groups
Time frame: Baseline, 3 months after treatment
Il-10 (pg) levels in GCF
Changes in IL-10 levels (determined by ELISA) 3 months after surgical periodontal treatment in Chronic and Aggressive periodontitis
Time frame: Baseline-3 months
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