Proof of Principle Study of Pulse Dosing of IL-15 to Deplete the Reservoir in HIV Infected People

Inclusion Criteria: 1. HIV-1 infected adults aged 18 years or over. 2. Stable ART for at least 36 months 3. Screening plasma HIV RNA levels below level of quantification (\<40 to \<50 copies RNA/mL depending on the assay) ≥ 2 years (a single measurement above the level of detection but \< 100-200 copies/ml will be allowed) 4. Screening CD4 count ≥500 cells/mm3 5. Laboratory tests performed within 14 days of study enrollment: 1. WBC ≥ 3000/mm3 2. Platelets ≥ 50,000/mm3 \[Patients may be transfused to meet this requirement\] 3. Hemoglobin ≥ 8 g/dL (\>80g/L) \[Patients may be transfused to meet this requirement\] 4. Calculated glomerular filtration rate (GFR) \>45 mL/min/1.73m2 5. Total bilirubin ≤ 2.0 X upper limit of institutional normal (ULN) 6. AST, ALT, ALP ≤ 2.0 X ULN 6. Adequate pulmonary function without any clinical sign of severe pulmonary dysfunction. PFTs \> 50% of predicted if symptomatic or prior known impairment. 7. Ability to be off prednisone and other immunosuppressive drugs for at least 14 days before first dose of study drug 8. Women of child bearing potential and men with partners of child bearing potential must agree to use effective contraception during therapy and for 4 months after completion of therapy 9. Voluntary written consent Exclusion Criteria: 1. Active infection other than HIV currently requiring systemic antimicrobial therapy 2. Previously treated on this study or received previous ALT-803 3. Latent TB infection or active TB disease prior to completing a standard regimen of anti-TB therapy 4. Active fungal infection requiring systemic antifungal therapy 5. Active or recurrent herpes or varicella-zoster virus infection requiring treatment (or chronic suppression) 6. Chronic hepatitis B or C 7. Planning or current pregnancy or breastfeeding 8. Intended modification of antiretroviral therapy in the next 24 weeks 9. NYHA (New York Heart Association) Class III or IV heart failure, uncontrollable supraventricular arrhythmias, any history of a ventricular arrhythmia, or other clinical signs of severe cardiac dysfunction 10. Symptomatic congestive heart failure, unstable angina pectoris, or Myocardial infarction within 6 months prior to screening 11. Marked baseline prolongation of QT/QTc interval (e.g. demonstration of a QTc interval greater than 500 milliseconds) 12. History or evidence of uncontrollable CNS disease 13. Prior organ allograft or allogeneic transplantation 14. On-going chronic systemic or regular inhaled corticosteroid use or other immunosuppressive therapy (a history of mild asthma not requiring therapy is eligible) 15. Psychiatric illness/social situations that would limit compliance with study requirements 16. Other illness that in the opinion of the investigator would exclude the patient from participating in this study