Study of SOM0226 in Familial Amyloid Polyneuropathy

Inclusion Criteria: * Participant is willing and able to give informed consent for participation in the study * Male or Female, aged 18 years or above at the time of consent * Two cohorts defined by TTR variant (wild type: healthy volunteers; TTR mutant: asymptomatic carriers with documented mutation in TTR or diagnosed TTR-FAP patients (stage 1 or 2) not undergoing pharmacological treatment with Vyndaqel * Body Mass Index (BMI) \> 17.5 kg/m2 * Female participants of child bearing potential and male participants whose partner is of child bearing potential must be willing to ensure that they or their partner use effective contraception during the study and for 2 month thereafter * Able (in the Investigators opinion) and willing to comply with all study requirements Exclusion Criteria: * Female participant who is pregnant, lactating or planning pregnancy during the course of the study * Evidence of history of clinically significant hepatic disease * An ALT or AST measurement \> 2 times the ULN (Upper Limit of Normal) * Scheduled elective surgery or other procedures requiring general anaesthesia during the study * Donation of blood during the study or within the past 4 weeks * Treatment (during the study or within the past 4 weeks) with a prescription or investigational drug for the treatment of TTR amyloidosis * Treatment with NSAIDs (nonsteroidal antiinflammatory drug) during the study or within the past 4 weeks. The following NSAID are allowed: acetylsalicylic acid, etodolac, ibuprofen, indomethacin, ketoprofen, nabumetone, naproxen, nimesulide, piroxicam and sulindac