The investigators investigated whether laparoscopic versus open surgical approaches affected the pharmacokinetic and pharmacodynamic of a single bolus dose of rocuronium or cisatracurium.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
100
Rocuronium 0.6 mg.kg-1 was administered within 5 s as an intravenous bolus
cisatracurium 0.15mg.kg-1 was administered within 5 s as an intravenous bolus
the blood flow in the right and middle hepatic veins
Measurements of the blood flow in the right and middle hepatic veins were performed at baseline and 1,5, 10, 20, 30min after insufflation of carbon dioxide or incise the skin as well as 1 and 5 min after deflation or close the wound.
Time frame: up to 9 months
the plasma Concentration of rocuronium and cisatracurium
Venous blood samples (3 ml) were taken 2 min prior to and at 5,30, 60 min following administration of rocuronium/cisatracurium.The aim of the present was to study the blood concentration of rocuronium/cisatracurium in laparoscopic surgery compared with conventional open gynaecological surgery
Time frame: up to 9 months
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