Flutiform® Compared With Seretide® in the Treatment of COPD

Inclusion: 1. Male or Female subjects aged ≥ 40 years at screening visit. 2. Diagnosis of COPD 3. Willing and able to replace current COPD therapy with study medication. 4. Able to demonstrate correct use of a pMDI with or without a spacer and Accuhaler. 5. Willing and able to attend all study visits and complete study assessments. 6. Able to provide signed informed consent. Exclusion: 1. Ongoing moderate or severe exacerbation of COPD in the 2 weeks before screening. 2. Current diagnosis of asthma. 3. Documented evidence of α1-antitrypsin deficiency as the underlying cause of COPD. 4. Other active respiratory disease such as active tuberculosis, lung cancer, bronchiectasis, sarcoidosis, lung fibrosis, pulmonary hypertension, interstitial lung disease, cystic fibrosis, bronchiolitis obliterans. 5. Previous lung resection. 6. Use of long-term oxygen therapy (LTOT) or mechanical ventilation. Note: LTOT is defined as \>15 hours use per day 7. Chest X-ray or CT scan that reveals evidence of clinically significant abnormalities not believed to be due to COPD. 8. Evidence of uncontrolled cardiovascular disease. 9. Evidence of clinically significant renal, hepatic, gastrointestinal, or psychiatric disease. 10. Current malignancy or a previous history of cancer which has been in remission for \< 5 years (basal cell or squamous cell carcinoma of the skin which has been resected is not excluded). 11. Clinically significant sleep apnoea requiring use of continuous positive airway pressure (CPAP) device or non-invasive positive pressure ventilation (NIPPV) device. 12. Participation in the acute phase of a pulmonary rehabilitation programme within 4 weeks prior to screening or during the study. 13. Known or suspected history of drug or alcohol abuse in the last 2 years. 14. Requiring treatment with any of the prohibited concomitant medications. 15. Known or suspected hypersensitivity to study drug or excipients. 16. Received an investigational drug within 30 days of the screening visit (12 weeks if an oral or injectable steroid).