Study to Evaluate Safety and Imunogenicity of Double Viral Vaccine (MR) for Measles and Rubella

Inclusion Criteria: * Male * Age between 18 and 49 years old; * Willing to provide name, address, telephone and other contact information in order to be contacted, whenever needed (example: in case of missing any scheduled visit, contact for confirmation of scheduling a visit, urgent safety notifications); * Willing to strictly follow the study protocol; * Capacity for understanding and signing in the Informed Consent Form; * To understand the impossibility of participating in another clinical trial during the time of participation in the study, until 6 months after its conclusion; * Intellectual level which allows to filling in the diaries for registering of symptoms at home; * Willing to undergo to serological testing to HIV, HBV and HCV; * Being in good health, with no significant medical history; * Physical examination at screening period without clinically significant changes; * Lab examination at screening period within the normal ranges, determined by the laboratory or abnormal values, grading below 1 or 2, according to medical decision. Exclusion Criteria: * Serious adverse reaction to any vaccination, as respiratory difficulty, angioedema and anaphylaxis; * Acute or chronic disease, as diabetes, heart disease, systemic arterial hypertension; * Use of anti-allergic with antigen injections in a maximum timeline of 14 days before the vaccination; * Use of immunoglobulin in the past 12 months before the study vaccination; * Use of blood products within 12 months before the vaccination; * Use of any vaccine type within 30 days before the vaccination of the study; * Chronic use of any medication, except homeopathy, and trivial ones, as nasal physiologic solution and vitamins; * Previous immunosuppressive or cytotoxic medication, in the last 6 months. Individuals who have made use of this kind of medication in non-immunosuppressant doses, as nasal corticosteroid for allergic rhinitis of topic corticosteroid for non-complicated dermatitis, for more than 14 days, are allowed to be included in the study. * Use of any kind of medication under investigation within one year before the vaccination. * Unstable asthma or which may have required urgent care, hospitalization or intubation within the last 2 years, or which requires use of oral or intravenous corticosteroid. * Coagulopathies diagnosed by a physician or report of capillary fragility (ex: bruises or bleedings without justifiable cause; * Convulsions, except the ones caused by fever, before 2 years old; * Psychiatric disease which difficults the adherence to the protocol, such as psychosis, obsessive-compulsive disorders, bipolar disease under treatment, diseases which require treatment with lithium and suicidal ideas in the last 5 years from the inclusion; * Active malignant (p.e. any kind of cancer) or treated disease, to which the individual may relapse during the study; * Asplenia (absence of spleen or its removal); * Positive HIV in the screening examination of history of any immunosuppressant disease; * Positive serology for C hepatitis in the screening evaluation; * Positive Antigen HBs in the screening evaluation; * Alcoholism (CAGE criteria), used for detection of abusive drinkers or alcoholic, validated in the Brazilian population with sensibility of 88% and specificity of 83%, if two or more answers, among four possible, are afirmative(Mansur and Monteiro, 1983), or according to medical decision; * Abuse of illicit drugs, according to medical decision; * Acquired or congenital immunodeficiency; * Allergy to the vaccine compounds, as egg, neomycin and gelatin.