A Phase II Trial of SGI-110 in Patients With IPSS High and Int 2 Myelodysplastic Syndrome, Acute Myeloid Leukemia With 20-30% Marrow Blasts or Chronic Myelomonocytic Leukemia Type 2 Not Responding to Azacitidine or Decitabine After at Least 6 Courses or Relapsing After a Response

Inclusion Criteria: * Myelodysplastic syndrome including the following categories of the WHO classification: refractory anemia with excess blasts (RAEB), non-proliferative chronic myelomonocytic leukemia (CMML) (leukocytes \< 13 G/L but \> 10% marrow blasts), AML with 20-30% marrow blasts (RAEB-T according to the FAB classification), at screening time. * Prior treatment with azacitidine or decitabine for at least 6 courses without response(CR, PR, marrow CR or stable disease with HI according to IWG 2006 criteria) or relapsing after a response. Non responders will be eligible only in the absence of overt progression, ie AML progression (if patients had no AML at onset of azacitidine/decitabine) or doubling of marrow blast percentage between onset of azacitidine/decitabine and screening * IPSS score \>1 (IPSS: Int-2 or High). * Age ≥ 18 years. * Normal liver function, defined by total bilirubin and transaminases less than 1.5 times the upper limit of normal. * Normal renal function, defined by creatinine less than 1.5 times the upper limit of normal, creatinine clearance ≥ 50 mL/min. * Patient is known not to be refractory to platelet transfusions. * Written informed consent. * Patient must understand and voluntarily sign consent form. * Patient must be able to adhere to the visit schedule as outlined in the study and follow protocol requirements. * ECOG performance status between 0-2 at the time of screening. * Women of chilbearing potential\* must: 1. Understand the study drug is expected to have a teratogenic risk 2. Agree to have a medically supervised pregnancy test on the day of the study visit or in the 3 days prior to the study visit once the subject has been on effective contraception for at least 4 weeks. This requirement also applies to women of childbearing potential who practice complete and continued abstinence. The test should ensure the subject is not pregnant when she starts treatment. 3. Agree to have a medically supervised pregnancy test every 4 weeks including 2 months after the end of study treatment, except in the case of confirmed tubal sterilization. These pregnancy tests should be performed on the day of the study visit or in the 3 days prior to the study visit. This requirement also applies to women of childbearing potential who practice complete and continued abstinence 4. Agree to use, and to be able to comply with, Two medically acceptable contraceptive measures without interruption, 4 weeks before starting study drug throughout the entire duration study drug therapy (including doses interruptions) and for 2 months after the end of the study drug therapy even if she has amenorrhoea. This applies unless the subject commits to absolute and continuous abstinence confirmed on a monthly basis, to avoid pregnancy for the duration of study. 5. Understand that even if she has amenorrhea, she must follow all the advice on effective contraception. 6. She understands the potential consequences of pregnancy and the need to rapidly consult if there is a risk of pregnancy * Men must: Agree to not conceive during the treatment and to use effective contraception during the treatment period (including periods of dose reduction or temporary suspension) and for a further 2 3 months after the end of treatment if their partner is of childbearing potential. Exclusion Criteria: * Severe infection or any other uncontrolled severe condition. * Significant cardiac disease - NYHA Class III or IV or having suffered a myocardial infarction in the last 6 months. * Less than 30 days since prior treatment with growth factors (EPO, G-CSF). * Use of investigational agents within 30 days or any anticancer therapy within 2 weeks before study entry with the exception of hydroxyurea. The patient must have recovered from all acute toxicities from any previous therapy. * Active cancer, or cancer during the year prior to trial entry other than basal cell carcinoma, or carcinoma in situ of the cervix or breast. * Patient already enrolled in another therapeutic trial of an investigational drug. * HIV infection or active hepatitis B or C. * Women who are or could become pregnant or who are currently breastfeeding. * Any medical or psychiatric contraindication that would prevent the patient from understanding and signing the informed consent form. * Patient eligible for allotransplantation. * Known allergy to SGI-110 or any of its excipients. * No affiliation to an insurance system.