The purpose of this study is to determine the influence of moderate FiO2 and the lung protective ventilation on postoperative pulmonary complications following hepatic resection surgery.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
280
First Affiliated Hospital, Sun Yat-Sen University
Guangzhou, Guangdong, China
RECRUITINGa composite of pulmonary and extrapulmonary complications occurring by day 7 after surgery.
The primary outcome was a composite of major pulmonary complications (defined as pneumonia or need for invasive or noninvasive ventilation for acute respiratory failure) and extrapulmonary complications (defined as sepsis, septic shock, or death) within the first 7 days after surgery.
Time frame: during the first seven days after surgery
incidence of pulmonary complications
the incidence of pulmonary complications due to any cause, graded on a scale from 0 (no pulmonary complications) to 4 (the most severe complications);extrapulmonary complications; durations of ICU and hospital stays;
Time frame: within the 30-day follow-up period
Oxidative stress markers
Oxidative stress markers variation in blood before anesthesia,during and after surgery , and compare with controls.
Time frame: 2 days
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