D-dimer Assay for the Exclusion of Intra-atrial Thrombus Risk Before Ablation of Atrial Fibrillation

N/ACompletedNCT02199080

Groupe Hospitalier de la Rochelle Ré Aunis2,506 enrolled

Overview

The purpose of this study is to determine whether D-dimer dosage allow to exclude risk of intraatrial thrombus before performing an ablation of atrial fibrillation

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

2,506

Conditions

Atrial Fibrillation

Interventions

D-dimer assay before ablation of atrial fibrillationOTHER

Blood sample collection for D-dimers measurement

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age\> 18 years. * Patients hospitalized for ablation of atrial fibrillation or symptomatic left flutter * Patient informed of the study Exclusion Criteria: * Age \<18 years. * Patients under guardianship * Pregnant woman * Contraindication to transesophageal echocardiography * transesophageal echocardiography made in another center as the center of ablation * Refusal of the patient to participate in the study * Patient participating in another interventional study in which an intervention related to biomedical research is performed before the transesophageal echocardiography

Locations (37)

Outcomes

Primary Outcomes

Number of Patients With Atrial Thrombus Diagnosed by Transoesophageal Ultrasound

Time frame: up to 48 hours before ablation

Secondary Outcomes

CHADS2 Score

CHADS2 score (congestive heart failure=1, hypertension=1, diabetes mellitus=1, history of stroke or transient ischemic attack=1, and age under 75=1)

Time frame: 48 hours before ablation

Risk Factors

variables related to the presence of atrial thrombus

Time frame: 48 hours before ablation

Atrial Thrombus Exclusion (ATE) Score

The following thromboembolic risk factors mark 1 point if present in patient: * hypertension = 1 point * cardiac insufficiency = 1 point * history of stoke = 1 point * d-dimer level \>270ng/mL = 1 point The sum corresponds to the ATE score

Time frame: 48 hours before ablation

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.

Service de cardiologie, CH de la Région d'Annecy

Annecy, France

Centre Hospitalier d' Auxerre

Auxerre, France

Service de cardiologie, CH Avignon

Avignon, France

Clinique La Fourcade

Bayonne, France

Service de cardiologie, CHU Bordeaux

Bordeaux, France

Service de cardiologie, CHU Brest

Brest, France

Service de cardiologie, CHU Caen

Caen, France

Service de cardiologie, CHU Clermont Ferrand

Clermont-Ferrand, France

Service de cardiologie, AP Hôpital Henri Mondor

Créteil, France

Service de cardiologie, CHU Dijon

Dijon, France

...and 27 more locations